{"id":41244,"date":"2022-12-23T18:01:59","date_gmt":"2022-12-23T16:01:59","guid":{"rendered":"https:\/\/mssociety.org.il\/?p=41244"},"modified":"2022-12-25T21:12:26","modified_gmt":"2022-12-25T19:12:26","slug":"types-of-ms","status":"publish","type":"post","link":"https:\/\/mssociety.org.il\/en\/types-of-ms\/","title":{"rendered":"Pioneering proposal for a new framework to describe types of MS"},"content":{"rendered":"<p><em><strong>This article has been adapted from one published by the National MS Society (US).<\/strong><\/em><\/p>\n<p>An international panel of MS experts has published a paper that proposes a new approach to how different types of MS are typically described. Currently, we use different descriptors to categorise types of MS, like\u00a0<a href=\"https:\/\/www.msif.org\/about-ms\/types-of-ms\/\">relapsing-remitting, primary progressive, or secondary progressive MS<\/a>, but there is growing evidence that MS is better understood as a continuous process. This process varies between individuals and over time, according to the way in which the nervous system is damaged, and how well an individual\u2019s body can repair or compensate for that damage. Moving away from traditional categories of MS may lead to new understanding, research and tools for better and more personalised treatments for MS.<\/p>\n<p>Any future framework for classifying MS will require a huge shift in how individuals with MS, clinicians, drug developers and regulators understand and describe MS. It will be essential to work closely with these groups as a new framework is developed, communicated and implemented. It is important to ensure any new measurements or tests required are practical and feasible across the diversity of global health systems.<\/p>\n<p>Describing MS based on the underlying processes occurring in the nervous system of each person, rather than how it appears clinically (e.g. whether or not an individual experiences relapses), will require a better understanding of how progression occurs in MS. The paper reviews ongoing research in this area, and identifies knowledge gaps.<\/p>\n<p>The panel\u2019s vision is that a new framework will support the development of the tools (for example\u00a0<a href=\"https:\/\/www.msif.org\/news\/2021\/04\/16\/what-is-a-biomarker\/\">biomarkers<\/a>\u00a0needed to detect an individual\u2019s disease course. In the future, such tools should be made available in clinical settings to inform treatment decisions, leading to better outcomes for people with MS.<\/p>\n<p>The proposal paper, by Tanja Kuhlmann, MD (University Hospital M\u00fcnster, Germany) and collaborators, was written on behalf of the\u00a0<a href=\"https:\/\/nms2cdn.azureedge.net\/cmssite\/nationalmssociety\/media\/msnationalfiles\/research\/international-advisory-committee-on-clinical-trials-in-multiple-sclerosis.pdf\">International Advisory Committee on Clinical Trials in MS<\/a>. This Committee includes representatives from MSIF\u2019s\u00a0<a href=\"https:\/\/www.msif.org\/about-us\/governance\/international-medical-and-scientific-board\/\">International Medical and Scientific Board<\/a>\u00a0(IMSB), and provides guidance related to planning and implementing clinical trials for new MS treatments.\u00a0The Committee is jointly supported by the National MS Society (US) and the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). Professor Takashi Yamamura, one of MSIF\u2019s IMSB members, has also written a\u00a0<a href=\"https:\/\/www.thelancet.com\/journals\/laneur\/article\/PIIS1474-4422(22)00469-0\/fulltext\">commentary on this publication<\/a>.<\/p>\n<p>You can access the scientific paper here:<\/p>\n<p>\u201c<a href=\"https:\/\/www.thelancet.com\/journals\/laneur\/article\/PIIS1474-4422(22)00289-7\/fulltext\">Multiple sclerosis progression: time for a new mechanism-driven framework<\/a>\u201d by Drs. Tanja Kuhlmann, Marcello Moccia, Timothy Coetzee, Jeffrey A. Cohen, Jorge Correale, Jennifer Graves, Ruth Ann Marrie, Xavier Montalban, V. Wee Yong, Alan J. Thompson, Daniel S. Reich, on behalf of the\u00a0<a href=\"https:\/\/nms2cdn.azureedge.net\/cmssite\/nationalmssociety\/media\/msnationalfiles\/research\/international-advisory-committee-on-clinical-trials-in-multiple-sclerosis.pdf\">International Advisory Committee on Clinical Trials in Multiple Sclerosis<\/a>, was published 18 November 2022 in Lancet Neurology.<\/p>\n<p><em><strong>Our thanks to the National MS Society who originally published this article.<\/strong><\/em><\/p>\n<p><span style=\"font-size: 8pt;\">Photo: Robina Weermeijer \u2013 Unsplash<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Moving away from traditional clinical categories of MS may lead to better, and more personalised treatments for MS.<\/p>\n","protected":false},"author":2,"featured_media":41239,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[423,384],"tags":[],"class_list":["post-41244","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-what-is-multiple-sclerosis-glossary-of-terms","category-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pioneering proposal for a new framework to describe types of MS - The Israel Multiple Sclerosis Society<\/title>\n<meta name=\"description\" content=\"Moving away from traditional clinical categories of MS may lead to better, and more personalised treatments for MS.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mssociety.org.il\/en\/types-of-ms\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pioneering proposal for a new framework to describe types of MS - The Israel Multiple Sclerosis Society\" \/>\n<meta property=\"og:description\" content=\"Moving away from traditional clinical categories of MS may lead to better, and more personalised treatments for MS.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mssociety.org.il\/en\/types-of-ms\/\" \/>\n<meta property=\"og:site_name\" content=\"The Israel Multiple Sclerosis Society\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/agudaims\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-23T16:01:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-12-25T19:12:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mssociety.org.il\/wp-content\/uploads\/2022\/12\/robina-weermeijer-IHfOpAzzjHM-unsplash-scaled.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1440\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"nathalie\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"nathalie\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/mssociety.org.il\/en\/types-of-ms\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/mssociety.org.il\/en\/types-of-ms\/\"},\"author\":{\"name\":\"nathalie\",\"@id\":\"https:\/\/mssociety.org.il\/en\/#\/schema\/person\/2da471395d8258fabafcce215ad71924\"},\"headline\":\"Pioneering proposal for a new framework to describe types of MS\",\"datePublished\":\"2022-12-23T16:01:59+00:00\",\"dateModified\":\"2022-12-25T19:12:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/mssociety.org.il\/en\/types-of-ms\/\"},\"wordCount\":482,\"publisher\":{\"@id\":\"https:\/\/mssociety.org.il\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/mssociety.org.il\/en\/types-of-ms\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/mssociety.org.il\/wp-content\/uploads\/2022\/12\/robina-weermeijer-IHfOpAzzjHM-unsplash-scaled.jpeg\",\"articleSection\":[\"What is Multiple Sclerosis &amp; 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