ראשי » About Multiple Sclerosis » Therapeutic information by pharmaceutical companies » MRI results in patients with CIS treated with interferon beta-1b: 11-year follow up in BENEFIT (BENEFIT 11)

MRI results in patients with CIS treated with interferon beta-1b: 11-year follow up in BENEFIT (BENEFIT 11)

ECTRIMS Online Library. Barkhof F.

ECTRIMS Online Library. Barkhof F. | Updated 02.03.2016

Background: Patients with clinically isolated syndrome (CIS) who had early treatment with interferon beta-1b in the BENEFIT trial had significantly better clinical outcomes up to 8 years after randomization when compared with patients who had a short delay. Outcomes on MRI were also more favorable with earlier treatment at the end of the placebo-controlled phase after 2 years up to the 5-year analysis; MRI was not assessed at Year 8.

Objective: To report MRI findings at 11 years post-randomization

Conclusions: Compared with cohorts with similar disease duration, patients in BENEFIT had a relatively low lesion volume with little evidence of brain atrophy, both supportive of early treatment with interferon beta-1b for patients with CIS.

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